A New Valid Formula in Differentiating Iron Deficiency Anemia from ß–thalassemia Trait
نویسنده
چکیده
Objective: To compare the validity of a new index (Hb×RDW×100/ (RBC)2×MCHC) with twelve discriminating functions (DFs) to differentiate iron deficiency anemia (IDA) and beta-thalassemia trait(ß –TT). Methodology: A total of 823 patients (317 IDA and 506 ß –TT) aged 15 to 35yearold were enrolled in this study. The diagnostic sensitivity, specificity and other validity parameters were calculated to assess the diagnostic reliability of the novel index [Keikhaei index (KI)] vis-a-vis the other published DFs [Mentzer Index (MI), Green & King Index (G&KI),red cell distribution width index (RDWI), England & Fraser Index (E&FI), Bessman and Feinstein index (B&FI), Telmissani et al index (TI), Srivastava and Bevington index (S&BI), Shine and Lal index (S&LI), Ricerca et al index (RI), Ehsani et al index (EI), Sirdah et al index (SI), and Red Blood Cell Count(RBC)] were calculated in all patients. Results: All thirteen DFs didn’t have the sensitivity and specificity of 100%. The KI, RDWI, G&KI and E&FI showed the most sensitivity and specificity for both IDA and TT; moreover, the lowest reliable indices belonged to B&FI, S&LI and RI. Conclusion: According to Youden’s index (YI), DFs in the order of highest to lowest were KI > G&KI > RDWI > E&FI > RBC> M I> EI > TI > SI > S&BI > RI> S&LI >B&FI.
منابع مشابه
Diagnostic reliability check of red cell indices in differentiating Iron Deficiency Anemia (IDA) from Beta Thalassemia Minor (BTT)
Introduction: Iron deficiency anemia and beta-thalassemia trait are the two most common causes of hypochromic microcytic anemia. There are some discriminating functions (DFs) formula to differentiate these two conditions based on RBC's indices which would be compared the validity of the 14 various indices in this study. Correspond...
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